Laboratório de Nanotecnologia e Nanomedicina

Sobre o LNMed


O Laboratório de Nanotecnologia e Nanomedicina (LNMed) vem crescendo ano após ano com a aprovação de projetos da FAPITEC, BNB e Capes. No LNMed vem sendo desenvolvidos trabalhos na área de nanopartículas (lipídicas, poliméricas e metálicas) para encapsulação de fármacos, proteínas e cosméticos; membranas poliméricas; hidrogéis e enxertos. As áreas de atuação do laboratório são Nanotecnologia, Nanomedicina e Biomaterial.

E-mail: lnmed@itp.org.br 

Contato: (79) 3218 2190 R 2599



Coordenação

Dra. Patricia Severino
Lattes


Pesquisadores



Estudantes

Luciana Nalone Andrade - Pós Doutorando
Camila Gomes Dantas - Doutorando
Carine Santana Ferreira - Doutorando
Daniele Martins de Lima - Doutorando
Diego Batista Menezes - Doutorando
Jônatas dos Santos Souza - Doutorando
Kahynna Cavalcante Loureiro - Doutorando
Rodrigo Figueiredo Fontes - Doutorando
Anne Caroline B. Vasconcellos - Mestrando
Leonardo de Araujo Lisboa - Iniciação Científica
Lucas Rannier Melo de Andrade - Iniciação Científica
Polyana Santos Rezende - Iniciação Científica
Thallysson Barbosa - Iniciação Científica


Produção Científica

Artigo -

Andrade, George R.S.; NASCIMENTO, Cristiane da Cunha; LIMA, ZENON M.; TEIXEIRA-NETO, ERICO; Costa, L. P.; Gimenez, Iara F.. Star-shaped ZnO/Ag hybrid nanostructures for enhanced photocatalysis and antibacterial activity. Applied Surface Science, v. 399, p. 573-582, 2017.


Artigo -

TAKEDA, TATIANE; CARVALHO VILA, MARTA M. D.; SANT ANA, LUCIANE L.; Severino, Patrícia; BALCAO, VICTOR M.; DE SOUZA, JULIANA FONSECA; ALVES, THAIS FRANCINE RIBEIRO; JUNIOR, JOSE MARTINS O.; CHAUD, Marco Vinicius. Development of fortified bread using peptide-iron chelate: A perspective to prevent iron deficiency anemia. Journal of Public Health Aspects, v. 3, p. 1, 2016.


Artigo -

MARONEZE, C. M.; DOS SANTOS, GLAUCO P.; DE MORAES, VITORIA B.; Costa, L. P.; KUBOTA, LAURO TATSUO. Multifunctional Catalytic Platform for Peroxidase Mimicking, Enzyme Immobilization and Biosensing. Biosensors & Bioelectronics, v. 77, p. 746-751, 2016.


Artigo -

SANTOS, JOSE C.; MATOS, CHARLENE R.S.; PEREIRA, GEORGE B.S.; SANTANA, TIAGO B.S.; SOUZA, HELIO O.; Costa, Luiz P.; SUSSUCHI, ELIANA M.; SOUZA, ANNE M.G.P.; Gimenez, Iara F.. Stable CdTe nanocrystals grown in situ in thiol-modified MCM-41 mesoporous silica: Control synthesis and electrochemical detection of Cu2+. Microporous and Mesoporous Materials (Print), v. 221, p. 48-57, 2016.


Artigo -

MATOS, CHARLENE REGINA SANTOS; CANDIDO, LUAN P.M.; SOUZA, HELIO OLIVEIRA; da Costa, Luiz Pereira; SUSSUCHI, ELIANA MIDORI; Gimenez, Iara F.. Study of the aqueous synthesis, optical and electrochemical characterization of alloyed ZnxCd1-xTe nanocrystals. Materials Chemistry and Physics, v. 222, p. 1-8, 2016.


Artigo -

SILVA, LAYS S.R.; LÓPEZ-SUÁREZ, FRANZ E.; PEREZ-CADENAS, M.; SANTOS, SYDNEY F.; da Costa, Luiz P.; EGUILUZ, KATLIN I.B.; SALAZAR-BANDA, GIANCARLO R.. Synthesis and characterization of highly active Pbx@Pty/C core-shell nanoparticles toward glycerol electrooxidation. Applied Catalysis. B, Environmental (Print), v. 198, p. 38-48, 2016.


Artigo -

SILVA SANTOS, KLEBSON; BARBOSA, ANDRIELE; PEREIRA DA COSTA, LUIZ; PINHEIRO, MALONE; OLIVEIRA, MARIA; FERREIRA PADILHA, FRANCINE. Silver Nanocomposite Biosynthesis: Antibacterial Activity against Multidrug-Resistant Strains of Pseudomonas aeruginosa and Acinetobacter baumannii. Molecules (Basel. Online), v. 21, p. 1255, 2016.


Artigo -

CIRINO, LORENA M.D.; VERGNE, DAVIANE M.C.; SANTANA, PATRÍCIA F.; ALMEIDA, ENRIK DE; COSTA, LUIZ P. DA; ALBUQUERQUE-JÚNIOR, RICARDO L.C. DE; LIMA-VERDE, ISABEL B.; Padilha, Francine F.; Cardoso, Juliana C.. Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes. Anais da Academia Brasileira de Ciências (Online), v. 88, p. 1539-1547, 2016.


Artigo -

CARDOSO, GUSTAVO DE BRITO ; SOUZA, ISABELA NASCIMENTO ; PEREIRA, MATHEUS M. ; Costa, Luiz Pereira ; FREIRE, MARA G. ; SOARES, CLEIDE MARA FARIA ; LIMA, ÁLVARO SILVA . Poly(vinyl alcohol) as a novel constituent to form aqueous two-phase systems with acetonitrile: Phase diagrams and partitioning experiments. Chemical Engineering Research & Design, v. 94, p. 317-323, 2015.


Artigo -

Severino, P.; SZYMANSKI, M.; FAVARO, M.; AZZONI, A.; SILVA, A. M.; Souto, E. B.; SANTANA, M. H. A.. Development and characterization of a cationic lipid nanocarrier as non-viral vector for gene therapy. European Journal of Pharmaceutical Sciences, v. 1, p. 5, 2015.


Artigo -

Severino, Patrícia; Andreani, Tatiana; CHAUD, Marco Vinicius; BENITES, C.; Pinho, Samantha C.; Souto, E. B.. Essential Oils as Active Ingredients of Lipid Nanocarriers for Chemotherapeutic Use. Current Pharmaceutical Biotechnology (Print), v. 16, p. 365-370, 2015.


Artigo -

Severino, Patrícia; CHAUD, M. V.; SHIMOJO, A.; ANTONINI, D.; LANCELLOTI, M.; Santana, M. H. A.; Souto, E. B.. Sodium alginate-cross-linked polymyxin B sulphate-loaded solid lipid nanoparticles: Antibiotic resistance tests and HaCat and NIH/3T3 cell viability studies. Colloids and Surfaces. B, Biointerfaces (Print), p. press, 2015.


Artigo -

Severino, Patrícia; SILVEIRA, E. F.; VAZZANA, M.; Chaud, M.V.; Santana, Maria Helena A.; SOUTO, E. B.. Validation of UV spectrophotometric assay for quantification of polymyxin B in solid lipid nanoparticles. Die Pharmazie (Berlin), v. 70, p. 693-697, 2015.


Artigo -

ALMEIDA, N. M. G.; LIMA, R.; ALVES, T. F. R.; ARAUJO, M.; Severino, Patrícia; CHAUD, Marco Vinicius. A novel dosage form for buccal administration of bupropion. Brazilian Journal of Pharmaceutical Sciences (Online), v. 51, p. 91-100, 2015.


Artigo -

REBELO, M. A.; ALVES, T. F. R.; LIMA, R.; OLIVEIRA JR, J. M.; VILA, M. M.; BALCAO, V. M.; Severino, Patrícia; CHAUD, M. V.. Scaffolds and tissue regeneration: An overview of the functional properties of selected organic tissues. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, p. n/a-n/a, 2015.


Artigo -

FERREIRA DA SILVA, CLASSIUS; Severino, Patrícia; Martins, Fernanda; SANTANA, M. H. A.; Souto, Eliana B.. Didanosine-loaded chitosan microspheres optimized by surface-response methodology: A modified -Maximum Likelihood Classification- approach formulation for reverse tranase inhibitors. Biomedicine & Pharmacotherapy, v. 70, p. 46-52, 2015.


Artigo -

SOUZA, E.E.S.; SANTOS, A.F.T.O.; GONZAGA, I.M.D.; ALVES, N.R.; COSTA, L.P.; SILVA, L.S.R.; EGUILUZ, K.I.B.; SALAZAR-BANDA, G.R.; CAVALCANTI, E.B.. Ruthenium-tin oxides-coated graphite felt: Enhanced active area and improved efficiency for the electrochemical generation of hydrogen peroxide. Ceramics International, v. 41, p. 10293-10297, 2015.


Artigo -

Lima, C. M. ; Serafini, M. R. ; SANTOS, G. P. ; Cardoso, J. C. ; FIGUEIREDO, R. T. ; SANTOS, M. S. ; MELO, M. G. D. ; SILVA, F. A. R. ; da Costa, L. P. ; SANTOS, A. F. C. ; ALBUQUERQUE-JÚNIOR, R. L. C. ; QUINTANS-JÚNIOR, L. J. ; Araújo, A. A. S. . Use of bone physicochemical characterization and biochemical analyses in an experimental model. Journal of Thermal Analysis and Calorimetry, v. 1, p. 1-6, 2015.


Artigo -

SANTOS, G.O.S.; SILVA, R.S.; COSTA, L.P.; CELLET, T.S.P.; RUBIRA, A.F.; EGUILUZ, K.I.B.; SALAZAR-BANDA, G.R.. Influence of synthesis conditions on the properties of electrochemically synthesized BaTiO3 nanoparticles. Ceramics International, v. 40, p. 3603-3609, 2014.


Artigo -

Lopes, D. T.; SHITARA, P. P. L.; BORGES, L. C. F. S.; Severino, P.; Pires, L. A.; Delgado, G. L.; CHAUD, Marco Vinícius. Oral Appliances to Prevent and Treat Acute Induced Mucositis With Oral Chemotherapy and Radiotherapy. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, v. 117, p. e216, 2014.


Artigo -

Severino, Patrícia; Andreani, Tatiana; JÄGER, ALESSANDRO; CHAUD, MARCO V.; Santana, Maria Helena A.; Silva, Amélia M.; Souto, Eliana B.. Solid Lipid Nanoparticles for Hydrophilic Biotech Drugs: Optimization and Cell Viability Studies (Caco-2 & HEPG-2 cell lines). European Journal of Medicinal Chemistry, v. 81, p. 28-34, 2014.


Artigo -

Severino, Patrícia; SILVA, C. F.; DA SILVA, MARIANA A.; SANTANA, MARIA H. A.; SOUTO, ELIANA B.. Chitosan Cross-Linked Pentasodium Tripolyphosphate Micro/Nanoparticles Produced by Ionotropic Gelation. Sugar Tech, v. xx, p. xx-xx, 2014.


Artigo -

Severino, P.; CHORILLI, M.; Santana, M. H. A.. PROCESSO DE OBTENÇÃO DE NANOPARTÍCULAS LIPÍDICAS SÓLIDAS, NANOPARTÍCULAS LIPÍDICAS SÓLIDAS E SEU USO. 2014, Brasil.


Artigo -

Maroneze, Camila M.; RAHIM, ABDUR ; FATTORI, NATÁLIA; Costa, L. P.; SIGOLI, F. A.; Sigoli, Fernando A.; Mazali, Italo O.; CUSTODIO, ROGÉRIO ; Gushikem, Yoshitaka . Electroactive Properties of 1-propyl-3-methylimidazolium Ionic Liquid Covalently Bonded on Mesoporous Silica Surface: Development of an Electrochemical Sensor Probed for NADH, Dopamine and Uric Acid Detection. Electrochimica Acta, v. 123, p. 435-440, 2014.


Artigo -

Barin, Gabriela Borin ; FÁTIMA GIMENEZ, IARA; Costa, Luiz Pereira; FILHO, ANTÔNIO GOMES SOUZA ; BARRETO, LEDJANE SILVA . Hollow carbon nanostructures obtained from hydrothermal carbonization of lignocellulosic biomass. Journal of Materials Science, v. 49, p. 665-672, 2014.


Artigo -

Barin, Gabriela Borin; Iara F. Gimenez; Ledjane S. Barreto; FILHO, ANTÔNIO GOMES SOUZA; COSTA, L. P. Influence of hydrothermal carbonization on formation of curved graphite structures obtained from a lignocellulosic precursor. Carbon (New York), v. 78, p. 609-612, 2014.


Artigo -

George R. S. Andrade; NASCIMENTO, C. C.; Ledjane S. Barreto; Iara F. Gimenez; Costa, Luiz P.. Cu-doped CdS and ZnS nanocrystals grown onto thiolated silica-gel. Optical Materials (Amsterdam. Print), p. 159-195, 2014.


Artigo -

DE SOUSA, ADRIANO FREITAS; BRAGA, TIAGO PINHEIRO; ABREU, JESSICA MIRANDA; da Costa, Luiz Pereira; DE VASCONCELOS, IGOR FROTA; BECKER, HELENA; VALENTINI, ANTONINHO; LONGHINOTTI, ELISANE . Synthesis of copper on iron/aluminum oxide mesoporous spheres and application on denitrification reaction. Chemical Engineering Journal (1996), v. 255, p. 290-296, 2014.


Artigo -

ANDRADE, GEORGE RICARDO SANTANA; NASCIMENTO, CRISTIANE DA CUNHA; MATOS, CHARLENE REGINA SANTOS ; SUSSUCHI, ELIANA MIDORI; COSTA, LUIZ PEREIRA D ; NASCIMENTO, KYRIA SANTIAGO DO ; CAVADA, BENILDO SOUSA ; GIMENEZ, IARA DE FÁTIMA . Study of the bioconjugation of ternary alloyed ZnCdTe nanocrystals to Concanavalin A. Journal of Photochemistry and Photobiology. A, Chemistry, v. 295, p. 46-52, 2014.


Artigo -

MELO, MATEUS SANTOS; SANTANA, RONEVAL FÉLIX ; BATISTA, CINTHIA MEIRELES; PINHEIRO, M. S.; Albuquerque, R. L. C.; Padilha, Francine Ferreira; LIMA, ÁLVARO SILVA; Nunes, Paula Santos; Costa, L. P.; Araújo, Adriano A.S.; Araújo, A. A. S.; CARDOSO, Juliana Cordeiro. Thermal characterization of mangaba-based films. Journal of Thermal Analysis and Calorimetry (Dordrecht Online), v. 111, p. 2097-2102, 2013.


Artigo -

Costa, Luiz P.; Freire, M. G.. The impact of self-aggregation on the extraction of biomolecules in ionic-liquid-based aqueous two-phase systems Separation and Purification Technology. Separation and Purification Technology (Print), v. 15453, p. 1-6, 2013.


Artigo -

Barin, Gabriela Borin; SANTOS, YANE HONORATO; ROCHA, JENNYFER ALVES; PEREIRA DA COSTA, LUIZ; SOUZA FILHO, ANTÔNIO GOMES; DE FÁTIMA GIMENEZ, IARA; BARRETO, LEDJANE SILVA. Graphene-like nanostructures obtained from Biomass. MRS Proceedings, v. 1505, p. 1-5, 2013.


Artigo -

Da Costa, Luiz Pereira.; QUITES JUNIOR, F. ; Sigoli, Fernando A.; Heloise de Oliveira Pastore ; Mazali, Italo Odone . Ag/lamellar hosts composites: a route to morphology-controllable synthesis of Ag nanoparticles. Journal of Nanoparticle Research, v. 15, p. 10.1007/s11051--14, 2013.


Artigo -

Strauss, M. ; DAMASCENO, J. P. V. ; MARONEZE, C. M. ; Costa, L. P. ; SIGOLI, F. A. ; GUSHIKEM, Y. ; MAZALI, I. O. . Exploring the functionalization ratio of mesoporous silica glass with imidazolium entities on the synthesis of supported gold nanoparticles. Journal of Nanoparticle Research, v. 15, p. 1441-1448, 2013.


Artigo -

Albuquerque, R. L. C.; Cardoso, J.C.; COSTA, L. P.; Souza, I.C.L.; Nascimento, M.F.; SOUZA NETA, R. G.; SANTOS, J. C.. Effect of the maltodextrin-induced chemical reticulation on the physical properties and healing potential of collagen-based membranes containing Brazilian red propolis extract. International Journal of Medicine and Medical Sciences, v. 5, p. 512-524, 2013.


Artigo -

Andrade, George R.S.; Nascimento, Cristiane C.; Neves, Erick C.; Barbosa, Cintya D Angeles Espirito Santo; Costa, Luiz P.; Barreto, Ledjane S.; Gimenez, Iara F.. One-step preparation of CdS nanocrystals supported on thiolated silica-gel matrix and evaluation of photocatalytic performance. Journal of Hazardous Materials (Print), v. 203-204, p. 151-157, 2012.


Artigo -

SEVERINO, Patricia; SILVA, C. F.; COSTA, T. C. T. D.; Silva, H.; CHAUD, M. V.; Santana, M. H. A.; Souto, E. B.. In vivo absorption of didanosine (ddI) formulated in chitosan microspheres composing pellets. In Vivo (Athens), v. 28, p. 1045-1050, 2014.


Artigo -

Nascimento, Cristiane C. ; ANDRADE, GEORGE R. S. ; NEVES, E. C. ; Neves, Erick C. ; Costa, L. P. ; BARBOSA, CINTYA D'ANGELES ESPIRITO SANTO ; Barreto, Ledjane S. ; Gimenez, Iara F. . Nanocomposites of CdS Nanocrystals with Montmorillonite Functionalized with Thiourea Derivatives and Their Use in Photocatalysis. Journal of Physical Chemistry. C. (Online), v. 116, p. 21992-22000, 2012.


Artigo -

MAZALI, I.O. ; FATTORI, NATALIA ; Maroneze, C.M. ; Costa, L. P. ; STRAUSS, MATHIAS ; MAZALI, I.O. ; Gushikem Y . Chemical and photochemical formation of gold nanoparticles supported on viologen-functionalized SBA-15. Colloids and Surfaces. A, Physicochemical and Engineering Aspects (Print), v. 1, p. 1, 2012.


Artigo -

Fattori, Natalia ; Maroneze, Camila M. ; Costa, L. P. ; Strauss, Mathias ; SIGOLI, F. A. ; Sigoli, Fernando A. ; Mazali, Italo O. ; Gushikem, Yoshitaka . Ion-Exchange Properties of Imidazolium-Grafted SBA-15 toward AuCl 4 - Anions and Their Conversion into Supported Gold Nanoparticles. Langmuir, v. 28, p. 10281-10288, 2012.


Artigo -

Juliana Faccin de Conto; Juciara dos Santos Nascimento; Driele Maiara Borges de Souza; Silvia Maria da Silva Egues; Lisiane dos Santos Freitas; Edilson Valmir Benvenutti; da Costa, Luiz Pereira. Solid Phase extraction of petroleum carboxilic acids using a functionalized alumina as stationary phase. Journal of Separation Science (Internet), v. 35, p. 1044-1049, 2012.


Artigo -

Da Costa, Luiz Pereira; Formiga, André Luiz Barboza ; Mazali, Italo Odone; Sigoli, Fernando Aparecido. Spontaneous formation of highly dispersed spheroidal metallic silver nanoparticles in surfactant-free N,N-dimethylacetamide. Synthetic Metals, v. 161, p. 1517-1521, 2011.