Laboratório de Nanotecnologia e Nanomedicina

Sobre o LNMed


O Laboratório de Nanotecnologia e Nanomedicina (LNMed) vem crescendo ano após ano com a aprovação de projetos da FAPITEC, BNB e Capes. No LNMed vem sendo desenvolvidos trabalhos na área de nanopartículas (lipídicas, poliméricas e metálicas) para encapsulação de fármacos, proteínas e cosméticos; membranas poliméricas; hidrogéis e enxertos. As áreas de atuação do laboratório são Nanotecnologia, Nanomedicina e Biomaterial.

E-mail: lnmed@itp.org.br 

Contato: (79) 3218 2190 R 2599



Coordenação

Dra. Patricia Severino
Lattes


Pesquisadores



Estudantes

Luciana Nalone Andrade - Pós Doutorando
Camila Gomes Dantas - Doutorando
Carine Santana Ferreira - Doutorando
Daniele Martins de Lima - Doutorando
Diego Batista Menezes - Doutorando
Jônatas dos Santos Souza - Doutorando
Kahynna Cavalcante Loureiro - Doutorando
Rodrigo Figueiredo Fontes - Doutorando
Anne Caroline B. Vasconcellos - Mestrando
Leonardo de Araujo Lisboa - Iniciação Científica
Lucas Rannier Melo de Andrade - Iniciação Científica
Polyana Santos Rezende - Iniciação Científica
Thallysson Barbosa - Iniciação Científica


Produção Científica

Artigo -

Andrade, George R.S.; NASCIMENTO, Cristiane da Cunha; LIMA, ZENON M.; TEIXEIRA-NETO, ERICO; Costa, L. P.; Gimenez, Iara F.. Star-shaped ZnO/Ag hybrid nanostructures for enhanced photocatalysis and antibacterial activity. Applied Surface Science, v. 399, p. 573-582.


Artigo -

TAKEDA, TATIANE; CARVALHO VILA, MARTA M. D.; SANT ANA, LUCIANE L.; Severino, Patrícia; BALCAO, VICTOR M.; DE SOUZA, JULIANA FONSECA; ALVES, THAIS FRANCINE RIBEIRO; JUNIOR, JOSE MARTINS O.; CHAUD, Marco Vinicius. Development of fortified bread using peptide-iron chelate: A perspective to prevent iron deficiency anemia. Journal of Public Health Aspects, v. 3, p. 1.


Artigo -

MARONEZE, C. M.; DOS SANTOS, GLAUCO P.; DE MORAES, VITORIA B.; Costa, L. P.; KUBOTA, LAURO TATSUO. Multifunctional Catalytic Platform for Peroxidase Mimicking, Enzyme Immobilization and Biosensing. Biosensors & Bioelectronics, v. 77, p. 746-751.


Artigo -

SANTOS, JOSE C.; MATOS, CHARLENE R.S.; PEREIRA, GEORGE B.S.; SANTANA, TIAGO B.S.; SOUZA, HELIO O.; Costa, Luiz P.; SUSSUCHI, ELIANA M.; SOUZA, ANNE M.G.P.; Gimenez, Iara F.. Stable CdTe nanocrystals grown in situ in thiol-modified MCM-41 mesoporous silica: Control synthesis and electrochemical detection of Cu2+. Microporous and Mesoporous Materials (Print), v. 221, p. 48-57.


Artigo -

MATOS, CHARLENE REGINA SANTOS; CANDIDO, LUAN P.M.; SOUZA, HELIO OLIVEIRA; da Costa, Luiz Pereira; SUSSUCHI, ELIANA MIDORI; Gimenez, Iara F.. Study of the aqueous synthesis, optical and electrochemical characterization of alloyed ZnxCd1-xTe nanocrystals. Materials Chemistry and Physics, v. 222, p. 1-8.


Artigo -

SILVA, LAYS S.R.; LÓPEZ-SUÁREZ, FRANZ E.; PEREZ-CADENAS, M.; SANTOS, SYDNEY F.; da Costa, Luiz P.; EGUILUZ, KATLIN I.B.; SALAZAR-BANDA, GIANCARLO R.. Synthesis and characterization of highly active Pbx@Pty/C core-shell nanoparticles toward glycerol electrooxidation. Applied Catalysis. B, Environmental (Print), v. 198, p. 38-48.


Artigo -

SILVA SANTOS, KLEBSON; BARBOSA, ANDRIELE; PEREIRA DA COSTA, LUIZ; PINHEIRO, MALONE; OLIVEIRA, MARIA; FERREIRA PADILHA, FRANCINE. Silver Nanocomposite Biosynthesis: Antibacterial Activity against Multidrug-Resistant Strains of Pseudomonas aeruginosa and Acinetobacter baumannii. Molecules (Basel. Online), v. 21, p. 1255.


Artigo -

CIRINO, LORENA M.D.; VERGNE, DAVIANE M.C.; SANTANA, PATRÍCIA F.; ALMEIDA, ENRIK DE; COSTA, LUIZ P. DA; ALBUQUERQUE-JÚNIOR, RICARDO L.C. DE; LIMA-VERDE, ISABEL B.; Padilha, Francine F.; Cardoso, Juliana C.. Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes. Anais da Academia Brasileira de Ciências (Online), v. 88, p. 1539-1547.


Artigo -

CARDOSO, GUSTAVO DE BRITO ; SOUZA, ISABELA NASCIMENTO ; PEREIRA, MATHEUS M. ; Costa, Luiz Pereira ; FREIRE, MARA G. ; SOARES, CLEIDE MARA FARIA ; LIMA, ÁLVARO SILVA . Poly(vinyl alcohol) as a novel constituent to form aqueous two-phase systems with acetonitrile: Phase diagrams and partitioning experiments. Chemical Engineering Research & Design, v. 94, p. 317-323.


Artigo -

Severino, P.; SZYMANSKI, M.; FAVARO, M.; AZZONI, A.; SILVA, A. M.; Souto, E. B.; SANTANA, M. H. A.. Development and characterization of a cationic lipid nanocarrier as non-viral vector for gene therapy. European Journal of Pharmaceutical Sciences, v. 1, p. 5.


Artigo -

Severino, Patrícia; Andreani, Tatiana; CHAUD, Marco Vinicius; BENITES, C.; Pinho, Samantha C.; Souto, E. B.. Essential Oils as Active Ingredients of Lipid Nanocarriers for Chemotherapeutic Use. Current Pharmaceutical Biotechnology (Print), v. 16, p. 365-370.


Artigo -

Severino, Patrícia; CHAUD, M. V.; SHIMOJO, A.; ANTONINI, D.; LANCELLOTI, M.; Santana, M. H. A.; Souto, E. B.. Sodium alginate-cross-linked polymyxin B sulphate-loaded solid lipid nanoparticles: Antibiotic resistance tests and HaCat and NIH/3T3 cell viability studies. Colloids and Surfaces. B, Biointerfaces (Print), p. press.


Artigo -

Severino, Patrícia; SILVEIRA, E. F.; VAZZANA, M.; Chaud, M.V.; Santana, Maria Helena A.; SOUTO, E. B.. Validation of UV spectrophotometric assay for quantification of polymyxin B in solid lipid nanoparticles. Die Pharmazie (Berlin), v. 70, p. 693-697.


Artigo -

ALMEIDA, N. M. G.; LIMA, R.; ALVES, T. F. R.; ARAUJO, M.; Severino, Patrícia; CHAUD, Marco Vinicius. A novel dosage form for buccal administration of bupropion. Brazilian Journal of Pharmaceutical Sciences (Online), v. 51, p. 91-100.


Artigo -

REBELO, M. A.; ALVES, T. F. R.; LIMA, R.; OLIVEIRA JR, J. M.; VILA, M. M.; BALCAO, V. M.; Severino, Patrícia; CHAUD, M. V.. Scaffolds and tissue regeneration: An overview of the functional properties of selected organic tissues. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, p. n/a-n/a.


Artigo -

FERREIRA DA SILVA, CLASSIUS; Severino, Patrícia; Martins, Fernanda; SANTANA, M. H. A.; Souto, Eliana B.. Didanosine-loaded chitosan microspheres optimized by surface-response methodology: A modified -Maximum Likelihood Classification- approach formulation for reverse tranase inhibitors. Biomedicine & Pharmacotherapy, v. 70, p. 46-52.


Artigo -

SOUZA, E.E.S.; SANTOS, A.F.T.O.; GONZAGA, I.M.D.; ALVES, N.R.; COSTA, L.P.; SILVA, L.S.R.; EGUILUZ, K.I.B.; SALAZAR-BANDA, G.R.; CAVALCANTI, E.B.. Ruthenium-tin oxides-coated graphite felt: Enhanced active area and improved efficiency for the electrochemical generation of hydrogen peroxide. Ceramics International, v. 41, p. 10293-10297.


Artigo -

Lima, C. M. ; Serafini, M. R. ; SANTOS, G. P. ; Cardoso, J. C. ; FIGUEIREDO, R. T. ; SANTOS, M. S. ; MELO, M. G. D. ; SILVA, F. A. R. ; da Costa, L. P. ; SANTOS, A. F. C. ; ALBUQUERQUE-JÚNIOR, R. L. C. ; QUINTANS-JÚNIOR, L. J. ; Araújo, A. A. S. . Use of bone physicochemical characterization and biochemical analyses in an experimental model. Journal of Thermal Analysis and Calorimetry, v. 1, p. 1-6.


Artigo -

SANTOS, G.O.S.; SILVA, R.S.; COSTA, L.P.; CELLET, T.S.P.; RUBIRA, A.F.; EGUILUZ, K.I.B.; SALAZAR-BANDA, G.R.. Influence of synthesis conditions on the properties of electrochemically synthesized BaTiO3 nanoparticles. Ceramics International, v. 40, p. 3603-3609.


Artigo -

Lopes, D. T.; SHITARA, P. P. L.; BORGES, L. C. F. S.; Severino, P.; Pires, L. A.; Delgado, G. L.; CHAUD, Marco Vinícius. Oral Appliances to Prevent and Treat Acute Induced Mucositis With Oral Chemotherapy and Radiotherapy. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, v. 117, p. e 216.


Artigo -

Severino, Patrícia; Andreani, Tatiana; JÄGER, ALESSANDRO; CHAUD, MARCO V.; Santana, Maria Helena A.; Silva, Amélia M.; Souto, Eliana B.. Solid Lipid Nanoparticles for Hydrophilic Biotech Drugs: Optimization and Cell Viability Studies (Caco-2 & HEPG-2 cell lines). European Journal of Medicinal Chemistry, v. 81, p. 28-34.


Artigo -

Severino, Patrícia; SILVA, C. F.; DA SILVA, MARIANA A.; SANTANA, MARIA H. A.; SOUTO, ELIANA B.. Chitosan Cross-Linked Pentasodium Tripolyphosphate Micro/Nanoparticles Produced by Ionotropic Gelation. Sugar Tech, v. xx, p. xx-xx.


Artigo -

Severino, P.; CHORILLI, M.; Santana, M. H. A.. PROCESSO DE OBTENÇÃO DE NANOPARTÍCULAS LIPÍDICAS SÓLIDAS, NANOPARTÍCULAS LIPÍDICAS SÓLIDAS E SEU USO. Brasil.


Artigo -

Maroneze, Camila M.; RAHIM, ABDUR ; FATTORI, NATÁLIA; Costa, L. P.; SIGOLI, F. A.; Sigoli, Fernando A.; Mazali, Italo O.; CUSTODIO, ROGÉRIO ; Gushikem, Yoshitaka . Electroactive Properties of 1-propyl-3-methylimidazolium Ionic Liquid Covalently Bonded on Mesoporous Silica Surface: Development of an Electrochemical Sensor Probed for NADH, Dopamine and Uric Acid Detection. Electrochimica Acta, v. 123, p. 435-440.


Artigo -

Barin, Gabriela Borin ; FÁTIMA GIMENEZ, IARA; Costa, Luiz Pereira; FILHO, ANTÔNIO GOMES SOUZA ; BARRETO, LEDJANE SILVA . Hollow carbon nanostructures obtained from hydrothermal carbonization of lignocellulosic biomass. Journal of Materials Science, v. 49, p. 665-672.


Artigo -

Barin, Gabriela Borin; Iara F. Gimenez; Ledjane S. Barreto; FILHO, ANTÔNIO GOMES SOUZA; COSTA, L. P. Influence of hydrothermal carbonization on formation of curved graphite structures obtained from a lignocellulosic precursor. Carbon (New York), v. 78, p. 609-612.


Artigo -

George R. S. Andrade; NASCIMENTO, C. C.; Ledjane S. Barreto; Iara F. Gimenez; Costa, Luiz P.. Cu-doped CdS and ZnS nanocrystals grown onto thiolated silica-gel. Optical Materials (Amsterdam. Print), p. 159-195.


Artigo -

DE SOUSA, ADRIANO FREITAS; BRAGA, TIAGO PINHEIRO; ABREU, JESSICA MIRANDA; da Costa, Luiz Pereira; DE VASCONCELOS, IGOR FROTA; BECKER, HELENA; VALENTINI, ANTONINHO; LONGHINOTTI, ELISANE . Synthesis of copper on iron/aluminum oxide mesoporous spheres and application on denitrification reaction. Chemical Engineering Journal (1996), v. 255, p. 290-296.


Artigo -

ANDRADE, GEORGE RICARDO SANTANA; NASCIMENTO, CRISTIANE DA CUNHA; MATOS, CHARLENE REGINA SANTOS ; SUSSUCHI, ELIANA MIDORI; COSTA, LUIZ PEREIRA D ; NASCIMENTO, KYRIA SANTIAGO DO ; CAVADA, BENILDO SOUSA ; GIMENEZ, IARA DE FÁTIMA . Study of the bioconjugation of ternary alloyed ZnCdTe nanocrystals to Concanavalin A. Journal of Photochemistry and Photobiology. A, Chemistry, v. 295, p. 46-52.


Artigo -

MELO, MATEUS SANTOS; SANTANA, RONEVAL FÉLIX ; BATISTA, CINTHIA MEIRELES; PINHEIRO, M. S.; Albuquerque, R. L. C.; Padilha, Francine Ferreira; LIMA, ÁLVARO SILVA; Nunes, Paula Santos; Costa, L. P.; Araújo, Adriano A.S.; Araújo, A. A. S.; CARDOSO, Juliana Cordeiro. Thermal characterization of mangaba-based films. Journal of Thermal Analysis and Calorimetry (Dordrecht Online), v. 111, p. 2097-2102.


Artigo -

Costa, Luiz P.; Freire, M. G.. The impact of self-aggregation on the extraction of biomolecules in ionic-liquid-based aqueous two-phase systems Separation and Purification Technology. Separation and Purification Technology (Print), v. 15453, p. 1-6.


Artigo -

Barin, Gabriela Borin; SANTOS, YANE HONORATO; ROCHA, JENNYFER ALVES; PEREIRA DA COSTA, LUIZ; SOUZA FILHO, ANTÔNIO GOMES; DE FÁTIMA GIMENEZ, IARA; BARRETO, LEDJANE SILVA. Graphene-like nanostructures obtained from Biomass. MRS Proceedings, v. 1505, p. 1-5.


Artigo -

Da Costa, Luiz Pereira.; QUITES JUNIOR, F. ; Sigoli, Fernando A.; Heloise de Oliveira Pastore ; Mazali, Italo Odone . Ag/lamellar hosts composites: a route to morphology-controllable synthesis of Ag nanoparticles. Journal of Nanoparticle Research, v. 15, p. 10.1007/s11051--14.


Artigo -

Strauss, M. ; DAMASCENO, J. P. V. ; MARONEZE, C. M. ; Costa, L. P. ; SIGOLI, F. A. ; GUSHIKEM, Y. ; MAZALI, I. O. . Exploring the functionalization ratio of mesoporous silica glass with imidazolium entities on the synthesis of supported gold nanoparticles. Journal of Nanoparticle Research, v. 15, p. 1441-1448.


Artigo -

Albuquerque, R. L. C.; Cardoso, J.C.; COSTA, L. P.; Souza, I.C.L.; Nascimento, M.F.; SOUZA NETA, R. G.; SANTOS, J. C.. Effect of the maltodextrin-induced chemical reticulation on the physical properties and healing potential of collagen-based membranes containing Brazilian red propolis extract. International Journal of Medicine and Medical Sciences, v. 5, p. 512-524.


Artigo -

Andrade, George R.S.; Nascimento, Cristiane C.; Neves, Erick C.; Barbosa, Cintya D Angeles Espirito Santo; Costa, Luiz P.; Barreto, Ledjane S.; Gimenez, Iara F.. One-step preparation of CdS nanocrystals supported on thiolated silica-gel matrix and evaluation of photocatalytic performance. Journal of Hazardous Materials (Print), v. 203-204, p. 151-157.


Artigo -

SEVERINO, Patricia; SILVA, C. F.; COSTA, T. C. T. D.; Silva, H.; CHAUD, M. V.; Santana, M. H. A.; Souto, E. B.. In vivo absorption of didanosine (ddI) formulated in chitosan microspheres composing pellets. In Vivo (Athens), v. 28, p. 1045-1050.


Artigo -

Nascimento, Cristiane C. ; ANDRADE, GEORGE R. S. ; NEVES, E. C. ; Neves, Erick C. ; Costa, L. P. ; BARBOSA, CINTYA D'ANGELES ESPIRITO SANTO ; Barreto, Ledjane S. ; Gimenez, Iara F. . Nanocomposites of CdS Nanocrystals with Montmorillonite Functionalized with Thiourea Derivatives and Their Use in Photocatalysis. Journal of Physical Chemistry. C. (Online), v. 116, p. 21992-22000.


Artigo -

MAZALI, I.O. ; FATTORI, NATALIA ; Maroneze, C.M. ; Costa, L. P. ; STRAUSS, MATHIAS ; MAZALI, I.O. ; Gushikem Y . Chemical and photochemical formation of gold nanoparticles supported on viologen-functionalized SBA-15. Colloids and Surfaces. A, Physicochemical and Engineering Aspects (Print), v. 1, p. 1.


Artigo -

Fattori, Natalia ; Maroneze, Camila M. ; Costa, L. P. ; Strauss, Mathias ; SIGOLI, F. A. ; Sigoli, Fernando A. ; Mazali, Italo O. ; Gushikem, Yoshitaka . Ion-Exchange Properties of Imidazolium-Grafted SBA-15 toward AuCl 4 - Anions and Their Conversion into Supported Gold Nanoparticles. Langmuir, v. 28, p. 10281-10288.


Artigo -

Juliana Faccin de Conto; Juciara dos Santos Nascimento; Driele Maiara Borges de Souza; Silvia Maria da Silva Egues; Lisiane dos Santos Freitas; Edilson Valmir Benvenutti; da Costa, Luiz Pereira. Solid Phase extraction of petroleum carboxilic acids using a functionalized alumina as stationary phase. Journal of Separation Science (Internet), v. 35, p. 1044-1049.


Artigo -

Da Costa, Luiz Pereira; Formiga, André Luiz Barboza ; Mazali, Italo Odone; Sigoli, Fernando Aparecido. Spontaneous formation of highly dispersed spheroidal metallic silver nanoparticles in surfactant-free N,N-dimethylacetamide. Synthetic Metals, v. 161, p. 1517-1521.